While Tom's very good at science, his brother is absolutely hopeless.

　　湯姆很擅長理科，而他的兄弟絕對是不可救藥。

　　This case is hopeless and he knows it.

　　這個案子毫無希望，這一點他是清楚的。

　　He's a hopeless case.

　　他是無可救藥了。

　　I'm hopeless at science.

　　我對理科一竅不通。

　　Our cat is hopeless at catching mice.

　　我們的貓絕對捉不到老鼠。

　　She felt lonely and hopeless.

　　她感到孤獨絕望。

　　We expected every drawing exercise to show us up as hopeless artists.

　　我們預計每次素描練習都會令我們看上去像是不成氣候的藝術家。

　　I knew I was going to make it — that I wasn't a hopeless case.

　　我就知道自己能挺過去——我還沒到山窮水盡的地步。

　　I'd be hopeless at working for somebody else

　　We are going to get into a hopeless muddle.

　　我們就要陷入無可救藥的混亂。